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based on these results, the trial did not meet its primary objective of showing a similar reduction in hba1c with amaryl m glimepiride compared to metformin.

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food decreases the extent of and slightly delays the absorption of metformin, as shown by approximately a 40 lower mean peak plasma concentration cmax , a 25 lower area under the plasma concentration versus time curve auc , and a 35 minute prolongation of time to peak plasma concentration tmax following administration of a single 850 mg tablet of metformin with food, compared to the same tablet strength administered fasting.

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in elderly patients, particularly those 80 years of age, renal function should be monitored regularly and, generally, amaryl m metformin hydrochloride hydrochloride tablets should not be titrated to the maximum dose see warnings and dosage and administration .

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